Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5557673 | Pharmacology & Therapeutics | 2017 | 106 Pages |
Abstract
Compound Chinese medicine (CCM) has been applied in clinics in China and some Asian nations for >Â 2000Â years. Studies over the past decades revealed the protective and therapeutic effect of CCMs and major ingredients on I/R-induced microcirculatory dysfunction and tissue injury in the heart, brain, liver, intestine, and so on. CCM contains diverse bioactive components with potential for energy metabolism regulation; antioxidant effect; inhibiting inflammatory cytokines release; adhesion molecule expression in leukocyte, platelet, and vascular endothelial cells; and the protection of thrombosis, albumin leakage, and mast cell degranulation. This review covers the major works with respect to the effects and underlying mechanisms of CCM and its ingredients on microcirculatory dysfunction and organ injury after I/R, providing novel ideas for dealing with this threat.
Keywords
AMPKNF-κBα-SMAMMPLPSTGF-β1COPTSITSAAMPCATBAITMPPALGPXHO-1mTORICAM-1Bcl-2ERSRASTCMCordyceps sinensisMBCMCP-1Angelica archangelicaSophora flavescensRESRAASRLCTLRUPRPKCeIF2αLC3CMMAT1ATF6BclHSYAPaeonolGinsenoside Rg1CTFHeme oxygenase-1WPTBaicalinpaeoniflorinGRP78Z-ligustilideTanshinone IIAGinsenoside Rb1RCTMOAPAEbaicaleinCTPSCURBCsRB1RGTCDTSFIGinsenoside RdRg1OMTSalvia miltiorrhizaRCDBBRGinsenoside Rg3Rg3Tanshinone IRehmannia glutinosaAstragalus membranaceusRhizoma CoptidisGinsenoside ReUncaria rhynchophyllaTXLtongxinluoScutellarinGinsenoside Rb3OxymatrineMLBDalbergia odoriferaPanax notoginsengRPRPNGMomordica charantiaRALPNotoginsenoside R1Xuebijing injectionL-THPShenfu InjectionRibosomal protein S19PI3-kinaseInositol-Requiring Enzyme-1αFlos CarthamiRadix bupleuriRadix Paeoniae RubraScutellaria BarbataRed blood cellsCCmI/RIRE1αLIGMAPKOGD/RROSTetramethylpyrazineWlsAdenosine TriphosphateATPadenosine monophosphateAstilbinASTAngiotensin IITight junctionAstragaloside IVEndoplasmic reticulum stressOstholeSchisandrin Bsalvianolic acid ASalvianolic acid BOstα-smooth muscle actinNADPH oxidaseischemia and reperfusioninterleukinBerberinedHIDLATransforming growth factor-β1Danhong injectionOxidative stresstumor necrosis factor alphaTUNELToll-like receptorAng IIResveratrolRadix scutellariaerhynchophyllinelight chain 3SalASODBBBSuperoxide dismutaseRenin-angiotensin-aldosterone systemendoplasmic reticulumtraditional Chinese medicineeukaryotic initiation factor 2αVascular endothelial growth factorTNF-αNuclear factor-kappa Bphosphatidylinositol-3 kinaseactivating transcription factor 6LADB-cell lymphoma-2Levo-tetrahydropalmatineMagnesium lithospermate Blipopolysaccharidematrix metallopeptidaseChinese materia medicaBlood-brain barrierEnergy metabolismintercellular adhesion molecule-1NADVascular permeabilityNitric oxidenicotinamide adenine dinucleotide phosphate-oxidaseNAD, nicotinamide adenine dinucleotidemammalian target of rapamycinHydroxysafflor yellow AUnfolded protein responsePalmatinemonocyte chemotactic protein 1glucose-regulated protein 78Protein kinase Cmitogen-activated protein kinaseprotocatechuic aldehydePERKAstragalus polysaccharideSMSRadix Angelicae Sinensisleft anterior descendingCatalaseCatalpolCaffeic acidGinkgo bilobaCoptisineglutathione peroxidaseReactive oxygen speciesANG II type 1 receptor
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Authors
Jing-Yan Han, Quan Li, Zhi-Zhong Ma, Jing-Yu Fan,