Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5557686 | Pharmacology & Therapeutics | 2017 | 18 Pages |
Abstract
Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Î9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Î9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.
Keywords
FAK2-arachidonoylglycerolHIF-1αEAECCLCBCCytochromes P450BDSAPP5-hydroxytryptamine receptor2-AGERKGPR55FAAHAβGSHCBDVGSCsEGFA2ACBGCOXAEAEGFRCyPCBDcannabigerolAcute lung injuryanandamideexperimental autoimmune encephalomyelitisFatty acid amide hydrolaseAliepithelial mesenchymal transitionBeta-amyloidChoChinese Hamster OvaryEMTCNSdelta-9-tetrahydrocannabinolColorectal cancerGlioma stem-like cellscentral nervous systemcyclo-oxygenaseendoplasmic reticulumepidermal growth factoracute myeloid leukemiachemokine (C-C motif) ligandamyloid precursor proteincannabidivarinCannabidiolcannabichromeneCRCextracellular signal-regulated kinasefocal adhesion kinaseGlutathioneAdenosine receptorAndrogen ReceptorEpidermal growth factor receptor
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Authors
Simona Pisanti, Anna Maria Malfitano, Elena Ciaglia, Anna Lamberti, Roberta Ranieri, Gaia Cuomo, Mario Abate, Giorgio Faggiana, Maria Chiara Proto, Donatella Fiore, Chiara Laezza, Maurizio Bifulco,