Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5557799 | Pharmacology & Therapeutics | 2017 | 45 Pages |
Abstract
The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare. We will examine their application in the engineering of vascular grafts, cardiac patches and bone substitutes as well as other tissue engineering applications and we will focus on their extensive use in the vascularization of engineered constructs. Additionally, we will discuss the emerging potential of human pericytes for the development of efficient, vascularized and non-immunogenic engineered constructs.
Keywords
PDGFR-βSKPsBMSCsECMTGFβFGFvWFBPSNG2EPCsPDGFPericytesHUVECSPLLAGFSSMCsTEVGRGS5CRBP1SMembBioactive factorsSM-MHCSVPSMSCsPGAPCLcpsα-SMALPSAFSPLGABFSGFAP3-dimensionalECsiPSneural/glial antigen 2Myocardial infarctionPoly-L-lactic acidBiomaterialsTransforming Growth Factor BetaPCsSmooth muscle myosin heavy chainBBBHuman umbilical vein endothelial cellsMesenchymal stem cellsbone marrow mesenchymal stem cellsInduced pluripotent stem cellsSmooth muscle cellsEndothelial progenitor cellsEndothelial cellsPerivascular cellsVon Willebrand factorsmooth muscle alpha-actinAngiogenic factorsGrowth factorsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet derived growth factorExtracellular matrixbrain blood barrierTissue engineeringMPsGlial fibrillary acidic proteinPoly(ethylene glycol)polytetrafluoroethylenePolycaprolactonePEGVascular graft
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Authors
Elisa Avolio, Valeria V. Alvino, Mohamed T. Ghorbel, Paola Campagnolo,