Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5557813 | Pharmacology & Therapeutics | 2016 | 15 Pages |
Abstract
Relationship between inflammation and cancer is now well-established and represents a paradigm that our immune response does not necessarily serves solely to protect us from infections and cancer. Many specific mechanisms that link chronic inflammation to cancer promotion and metastasis have been uncovered in the recent years. Here we are focusing on the effects that tumors may exert on inflammatory cascades, tuning the immune system ability to cause tumor promotion or regression. In particular, we discuss the contributions of chemokines, cytokines and exosomes to the processes such as induction of inflammation and tumorigenesis. Overall, tumor-elicited inflammation is a key driver of tumor progression and an essential component of tumor microenvironment.
Keywords
TNFMMPMDSCIGF2MCP-1PD-L1TGFβHIF-1STATinflammationExosomesinterleukinTAMTransforming Growth Factor BetaTumorCancerMyeloid-derived suppressor cellsCytokinesMIFhypoxia-inducible factor 1granulocyte colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)insulin-like growth factor 2G-CSFtumor necrosis factorMatrix metalloproteaseTumor-associated macrophagesSignal transducer and activator of transcriptionprogrammed death-ligand 1monocyte chemoattractant protein-1Chemokines
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Authors
K.-S.N. Atretkhany, M.S. Drutskaya, S.A. Nedospasov, S.I. Grivennikov, D.V. Kuprash,