Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
557824 | Web Semantics: Science, Services and Agents on the World Wide Web | 2006 | 9 Pages |
This paper describes the use of semantic web technology and Description Logic (DL) for facilitating the integration of molecular pathway data, which is illustrated by an Web Ontology Language (OWL)-based transformation of a more complex pathway structure (Reactome) into a simpler one (HPRD). The process starts by adding OWL axioms to BioPAX, a pathway interchange standard. The axioms are designed for mapping BioPAX-formatted Reactome interactions to “molecular binding event” interactions, which can be easily aligned with the HPRD data. Using an automated OWL reasoner, we find overlapping and non-overlapping molecular interactions between the two pathway datasets. The paper demonstrates the potential of semantic web and its enabling technologies in biological pathway data reasoning and integration.