Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5601701 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews | 2017 | 19 Pages |
Abstract
Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV) mortality and morbidity in general population and in individuals with known CV disease. Recent animal and clinical studies have shown that reduced number and weak function of endothelial progenitor cells (EPCs) may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation in patients with DM. Moreover, EPCs having a protective impact on the vasculature may mediate the functioning of other organs and systems. Therefore, EPCs dysfunction is probably promising target for DM treatment strategy, while the role of restoring of EPCs number and functionality in CV risk diminish and reduce of DM-related complications is not fully clear. The aim of the review is summary of knowledge regarding EPCs dysfunction in DM patients.
Keywords
HP1αNF-kappaBT2DMEPCsPKCMmpsRAASHUVECSDF-1NADPHHIF-1ROSAngiogenesisReparationcoronary artery diseaseDiabetes mellitusType 2 diabetes mellitusHuman umbilical vein endothelial cellsEndothelial progenitor cellsAgeCADCardiovascular complicationshypoxia-inducible factor-1granulocyte colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)G-CSFnuclear factor kappaBcardiovascularMetalloproteinasesAdvanced glycation end productsNitric oxidenicotinamide-adenine dinucleotide phosphateReactive oxidative species
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Authors
Alexander E. (Professor, Consultant of Therapeutic Unit),