| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5613978 | Journal of Arrhythmia | 2017 | 8 Pages |
Abstract
Pilsicainide penetrates the plasma membrane, stabilizes WT-hERG proteins by acting as a chemical chaperone, and enhances WT-hERG channel currents. This mechanism could also be applicable to modulations of certain mutant-hERG proteins.
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Authors
Takeshi MD, Ichiro MD, Yasutaka MD, Peili MD, Tomomi PhD, Kumi PhD, Naoyuki MD, Akio MD, Kazuhiko MD, Masaru MD, Junichiro MD, Haruaki MD, Katsumi PhD, Yasuaki PhD, Takashi BE, Toshiyuki PhD, Yoshinobu MD, Motonobu MD,