Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5614746 | Journal of Cardiology | 2017 | 9 Pages |
Abstract
The results suggested that, as a hitherto unrecognized supplying route, the human PCAT stores oxLDL and HDL and oxLDL is supplied to coronary intima either by CD68(+)-macrophages or vasa vasorum and HDL by vasa vasorum, and that deposition of oxLDL and HDL in the intima increased with plaque growth but the former decreased while the latter increased further with plaque maturation. Molecular therapy targeting PCAT before plaque maturation could be effective in preventing atherosclerosis.
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Authors
Yasumi MD, Yasuto MD, Ei MD, Nobuyuki MD, Toshihoko PhD, Soichiro PhD,