Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5615586 | Journal of Electrocardiology | 2017 | 4 Pages |
Abstract
Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. However, it is uncertain whether these actions are retained after ischemia/reperfusion. Using implanted telemetry transmitters, we examined the effects of prolonged, intra-myocardial growth hormone administration in conscious rats. During a 24-h observation period, ventricular tachyarrhythmias and sympathetic activation were attenuated in treated rats, whereas infarct-size was unchanged. These findings call for further study on the antiarrhythmic effects of growth hormone and on the underlying mechanisms.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Marianthi MD, Eleonora MSc, Maria MSc, Agapi D. MD, PhD, Giannis G. MD, PhD, Antonios P. MD, PhD, Simeon PhD, Theofilos M. MD, PhD,