Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5619539 | Progress in Cardiovascular Diseases | 2016 | 35 Pages |
Abstract
Hypertension (HTN) is a global health problem and a leading risk factor for cardiovascular disease (CVD) morbidity and mortality. The hemodynamic overload from HTN causes left ventricular (LV) remodeling, which usually manifests as distinct alterations in LV geometry, such as concentric remodeling or concentric and eccentric LV hypertrophy (LVH). In addition to being a common target organ response to HTN, LV geometric abnormalities are well-known independent risk factors for CVD. Because of their prognostic implications and quantifiable nature, changes in LV geometric parameters have commonly been included as an outcome in anti-HTN drug trials. The purpose of this paper is to review the relationship between HTN and LV geometric changes with a focus on (1) diagnostic approach, (2) epidemiology, (3) pathophysiology, (4) prognostic effect and (5) LV response to anti-HTN therapy and its impact on CVD risk reduction.
Keywords
CHDARBHTNFHSRAASRWTSCDHHDLVMRCTCMRLVHCCBThree-dimensionalLVEFRandomized controlled trialMyocardial infarctionAngiotensin converting enzyme inhibitorobstructive sleep apneaCardiac magnetic resonanceRemodelingConcentric remodelingOsacoronary heart diseasecardiovascular diseaseHypertensive heart diseasechronic kidney diseaseLeft ventricular masstwo-dimensionalDiabetes mellitusCVDLIFEMetabolic syndromerenin-angiotensin-aldosterone-systemRelative wall thicknessHypertensionhypertension or hypertensiveBlood pressureAtrial fibrillationMETSSudden cardiac deathBeta blockerCalcium channel blockerAngiotensin receptor blockerFramingham Heart StudyACEI یا angiotensin convert enzyme inhibitorheart failureCKDLeft ventricular geometryLeft ventricular hypertrophyleft ventricular ejection fraction
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Authors
Ahmet AfÅin Oktay, Carl J. Lavie, Richard V. Milani, Hector O. Ventura, Yvonne E. Gilliland, Sangeeta Shah, Michael E. Cash,