Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5619664 | Progress in Cardiovascular Diseases | 2016 | 12 Pages |
Abstract
Valvular heart disease is a common cause of increased mean pulmonary artery pressure (PAP). Aortic stenosis and mitral regurgitation are frequently accompanied by pulmonary hypertension (PH), especially when they are severe and symptomatic. In asymptomatic patients, PH is rare, though the exact prevalence is unknown and mainly stems from the severity of the valvular heart disease and the presence of diastolic dysfunction. Exercise echocardiography has recently gained interest in depicting PH. In these asymptomatic patients, exercise PH is observed in about >40%. Either PH at rest (systolic PAP >50 mmHg) or during exercise (systolic PAP >60 mmHg) is a powerful determinant of outcome and is independently associated with reduced survival, regardless of the severity of the underlying valvular pathology.
Keywords
ACTPulmonary acceleration timeTranspulmonary pressure gradientTPGVHDSPAPDPDPAPNYHAPAWPNew York Heart AssociationechocardiographyRight ventricularLeft ventricularvalvular heart diseaseAortic stenosisleft atrialPVRPulmonary artery pressuresystolic pulmonary artery pressurepulmonary capillary wedge pressurePulmonary vascular resistanceOutcomeexercisePulmonary hypertension
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Authors
Christophe Martinez, Anne Bernard, Raluca Dulgheru, Pierluigi Incarnato, Cécile Oury, Patrizio Lancellotti,