Adaptive prediction of epileptic seizures from intracranial recordings

Previous work has demonstrated that some dynamic properties of intracranial EEG signals are indicative of epileptic seizures and hence could be used for prediction in order to realize counter measures. However, most previous studies only investigated predictability via offline analysis of EEG signals as compared to actually predicting seizures in a setting applicable to implantable devices. Here we address this problem, which calls for simple and fast online methods, and based on previous offline analyses we hypothesize that prediction can be further improved when using multiple features to detect the preictal patterns. We propose a simple adaptive online method (an evolving neuro-fuzzy model) to adaptively learn such combined features. The classifier starts out with a simple structure and patient-independent parameters and then grows into a personal seizure predictor as recursive methods tune the model structure and parameters. We apply the adaptive classifier to a publicly available database of intracranial recordings from 21 patients and demonstrate that seizure prediction is improved with our online method as compared to offline non-adaptive techniques. We show that our method is robust with respect to those few model parameters, which are not adapted. Moreover, as we report the performance on data from a publicly available seizure database, our results can serve as a yardstick for future method developments.

► In this paper an adaptive online method for seizure prediction has been proposed. ► Most methods are offline predictors which are not applicable to implantable devices. ► The proposed predictor is able to adaptively learn pre-seizure patterns. ► The model starts out with a simple neuron and grows into a personal seizure predictor. ► Simulations results show that the proposed strategy outperforms a non-adaptive method.