| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5630146 | Journal of Neuroimmunology | 2017 | 4 Pages |
â¢Serum soluble Talin-1 (sTalin-1) levels were significantly higher in MS than normal controls (NCs).â¢The serum sTalin-1 levels were associated with a sustained increase in disability after an MS attack.â¢sTalin-1 may be a biomarker for the acute phase of MS and a therapeutic target for MS.
Previously, we identified anti-Talin-1 antibodies in the serum of MS. In this case, we measured the serum soluble Talin-1 (sTalin-1) levels by enzyme-linked immunosorbent assay. The serum sTalin-1 levels were significantly higher in 40 patients with MS than in 43 normal controls and in the acute phase of disease than in the remission phase. Interestingly, serum sTalin-1 levels were associated with a sustained increase in disability after MS attack but not with serum anti-Talin-1 antibody levels. sTalin-1 may be a biomarker for the acute phase of MS and may be used for the short-term prognosis of MS.
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