High serum creatinine is associated with reduction of vision impaired in patients with NMOSD

•Study on relationship between SCR level and vision impaired in NMOSD patients•High SCR was associated with a low occurrence of vision impaired in NMOSD patients.•High SCR level is a protective factor of vision impaired in male NMOSD patients.

Serum creatinine (SCR) has been found to be neuroprotective in neurodegenerative disease. However, whether SCR is a protective factor for vision impaired in neuromyelitis optica spectrum disorder (NMOSD) is unclear. This study to determine the relationship between SCR level and vision impaired in NMOSD patients through multivariate-adjusted linear regression analyses. Our result showed that high level of SCR was associated with a low occurrence of vision impaired, and the association was independent after adjustment for confounding risk factors and hierarchical analysis. Therefore, these results demonstrated that higher SCR level is a protective factor of vision impaired in male NMOSD patients.

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