| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5630320 | Journal of Neuroimmunology | 2017 | 11 Pages |
Abstract
We show for the first time by MRI volumetric methods that there is no correlation between histopathological characteristics and brain volume changes in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease. Utilizing a dose response study design, four months old F1 3xTg-AD/C3H mice were treated for 10Â months between ages 4 and 14Â months with laquinimod (5, 10, or 25Â mg/kg), or PBS administered by oral gavage. Brain volumes were measured in a 7 Tesla magnetic resonance imager (MRI) at ages 4 and 14Â months. There was no detectable reduction of brain volume over a period of 10Â months of treatment, as there was not brain atrophy in any of the control or treatment groups.140
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Authors
Rehana Z. Hussain, William A. Miller-Little, Doris Lambracht-Washington, Tom C. Jaramillo, Masaya Takahashi, Shanrong Zhang, Min Fu, Gary R. Cutter, Liat Hayardeny, Craig M. Powell, Roger N. Rosenberg, Olaf Stüve,