miRNA - rola i znaczenie w astmie oskrzelowej

Chronic inflammatory airway diseases, including asthma, are a significant health problem and previous treatment methods seem to be insufficient. There is a lack of effective therapies which are adjusted to treat all classes in terms of severity, and it is probably caused by insufficient understanding of molecular mechanisms involved in its occurrence. Small non-coding microRNA molecules in response to environmental factors lead to modulate gene expression. They regulate many processes associated with physiologic functions of the immune system. Researches showed crucial role of miRNA in pathogenesis of asthma and the other chronic inflammatory airway diseases. Despite the link of microRNA with pathogenesis of inflammatory airway diseases, the role of these molecules is still unclear. More detailed knowledge of the impact of miRNA molecules on the development of bronchial asthma would allow us to better understand the genesis process and might influence the effectiveness of the bronchial asthma treatment.