Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658432 | Gastroenterology | 2017 | 53 Pages |
Abstract
Peripheral CD4+ T cells from patients with ALF have increased expression of CTLA4 compared to individuals without ALF; these cells have a reduced response to antigen and CD3 stimulation. We found sera of patients with ALF and from mice with liver injury to have high concentrations of soluble B7, which up-regulates CTLA4 expression by T cells and reduces their response to antigen. Plasma exchange reduces levels of B7 in sera from patients with ALF and might be used to restore antimicrobial responses to patients.
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Authors
Wafa Khamri, Robin D. Abeles, Tie Zheng Hou, Amy E. Anderson, Ahmed El-Masry, Evangelos Triantafyllou, Christine Bernsmeier, Fin S. Larsen, Arjuna Singanayagam, Nobuaki Kudo, Lucia A. Possamai, Fanny Lebosse, Georg Auzinger, William Bernal,