| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5671507 | Clinical Microbiology and Infection | 2017 | 32 Pages |
Abstract
IFN-γ production, as well as the response to IFN-γ, is intact in chronic Q fever patients, and even higher than in healthy individuals. Polymorphisms in the IL-12p40 gene are associated with chronic Q fever. Thus, a deficiency in IFN-γ responses does not explain the failure to clear the infection. The genetic data suggest, however, that the IL-12/IFN-γ pathway does play a role.
Keywords
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Microbiology
Authors
T. Schoffelen, J. Textoris, C.P. Bleeker-Rovers, A. Ben Amara, J.W.M. van der Meer, M.G. Netea, J.-L. Mege, M. van Deuren, E. van de Vosse,