Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5671875 | Clinical Microbiology and Infection | 2016 | 27 Pages |
Abstract
We report the near-full-length genome sequence of a hepatitis C virus (HCV) isolate from a man originating from Democratic Republic of Congo, the genotype of which could not be determined by the routinely used sequencing technique. The near-complete genome sequence of this variant BAK1 was obtained by the association of two next-generation sequencing technologies. Evolutionary analysis indicates that this isolate, BAK1, could be the first reported strain belonging to a new HCV-7b subtype. This new subtype has been incorrectly identified as genotype 2 by the Versant HCV Genotype 2.0 assay (LiPA). The requirement of three independent isolates has been filled, and a new subtype can be assigned. More examples of HCV-7 are required to better understand its origin, its pathogenicity and its relationship with genotype 2.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
M. Salmona, A. Caporossi, P. Simmonds, M.-A. Thélu, K. Fusillier, S. Mercier-Delarue, N. De Castro, J. LeGoff, M.-L. Chaix, O. François, F. Simon, P. Morand, S. Larrat, S. Maylin,