Helicobacter pylori virulence factors in relation to gastrointestinal diseases in Iran

•Role of genotypes of H. pylori in creation of gastroduodenal diseases is different among various ethnic groups of Iran.•There have been some inconsistent reports about the cagA positivity and GC risk in Iran.•There are insufficient studies about dupA, cagA, -T, -G, -H, oipA, orf17 and homB genotypes of Helicobacter pylori in Iran.

PurposesHelicobacter pylori as an important pathogenic bacterium that colonizes in gastric mucosa, is one of the causative agents in development of some types of gastric diseases, such as chronic active gastritis, peptic ulcer disease (PUD) and gastric cancer (GC). In this review, the aim is studying different genotypes of H. pylori, and the extent of their participation in the pathogenesis of this bacterium which creates gastroduodenal disorders.ResultsSome genotypes of H. pylori have a major role in creation of gastroduodenal diseases, whereas some other genotypes of the bacterium do not cause gastric diseases in Iran. It was also reported that some genotypes of this bacterium in different conditions and among different ethnic groups demonstrate different effectiveness.ConclusionRole of genotypes of H. pylori in creation of gastroduodenal diseases is different among various regions and ethnic groups of Iran.