| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5737546 | Neuroscience | 2017 | 11 Pages |
Abstract
We suggest that a high-affinity PAC1 receptor pre-synaptically modulates hippocampal glutamatergic transmission acting through ACh. Therefore, administration of PACAP at very low doses might be envisaged in cognitive diseases with reduced cholinergic transmission.
Keywords
CA1cyclic adenosine mono phosphateAMPACA3aCSFmEPSCscAMPD-(−)-2-amino-5-phosphonopentanoic acidd-AP5EPSCfEPSPscornu ammonis 3cornu Ammonis 1AChAcetylcholineα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidlong-term depressionlong-term potentiationLTPexcitatory post-synaptic currentartificial cerebrospinal fluidLTDfield excitatory post-synaptic potentials
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Authors
Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Costa,