| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5809926 | European Journal of Pharmaceutical Sciences | 2014 | 9 Pages |
Abstract
A group of homochiral quaternary ammonium sulfonamides bearing hydrophobic camphor derived moieties were synthesized and characterized. The described synthetic procedure is quick and efficient. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents. They exhibited strong antimicrobial and also antifungal activity, especially N-{2-[((1S, 4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methylsulfonamido] ethyl}-N,N-dimethyltetradecan-1-aminium bromide 1c. The surface properties of prepared compounds were evaluated by surface tension measurements and critical micelle concentration (CMC) with surface tension at CMC (γCMC) was calculated.
Graphical abstractDownload high-res image (61KB)Download full-size image
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
R. MikláÅ¡, N. MikláÅ¡ová, M. Bukovský, B. Horváth, J. Kubincová, F. DevÃnsky,