Article ID Journal Published Year Pages File Type
5810165 European Journal of Pharmaceutical Sciences 2012 14 Pages PDF
Abstract

Dual- and multi-functional drug delivery systems, especially ligand-modified nanoparticles (NPs) loaded with chemotherapeutic agents are paid much attention to due to their excellent behavior in vitro and in vivo. Bifunctional NPs (BF-NPs), which were based on PLGA-PEG and modified with folic acid and cell penetrating peptide R7 simultaneously, were developed. BF-NPs loaded with vincristine sulfate (VCR) were prepared via the water-oil-water emulsion solvent evaporation method. BF-NPs showed favorable particle size and zeta potentials, promising drug loading and entrapment efficiency. The release of VCR from BF-NPs exhibited a biphase release manner. Cellular uptake of BF-NPs was found to be higher than that of the NPs merely modified by folic acid or R7. In vitro cytotoxicity, cell apoptosis and cell cycle arrest studies also revealed that BF-NPs were more potent than those of the NPs merely modified by folic acid or R7. Therefore, the results demonstrated that BF-NPs developed in this study could be a potential vehicle for delivering chemotherapeutic agents such as VCR and breast cancer therapy.

Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
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