pH sensitive polymeric complex of cisplatin with hyaluronic acid exhibits tumor-targeted delivery and improved in vivo antitumor effect

Article ID	Journal	Published Year	Pages	File Type
5818232	International Journal of Pharmaceutics	2015	38 Pages	PDF

Keywords

N-(2-Hydroxypropyl) methacrylamide HPMA PBS LLC CDDP i.v.DDS RES ALT 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide MTT AST Aspartate aminotransferase Alanine aminotransferase Enzyme-Linked Immuno-Sorbent Assay EPR effect Hyaluronic acid Tem ELISA Tumor targeting BUN Intravenous SMA Antitumor therapy Lewis lung cancer cisplatin Drug delivery system reticulo-endothelial System Phosphate buffered saline Transmission electron microscopy Enhanced permeability and retention effect blood urea nitrogen Poly(ethylene glycol)PEG creatinine high performance liquid chromatography HPLC

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmaceutical Science

pH sensitive polymeric complex of cisplatin with hyaluronic acid exhibits tumor-targeted delivery and improved in vivo antitumor effect

Authors

Xiaohong Fan, Xuesong Zhao, Xinkai Qu, Jun Fang,