Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5819734 | International Journal of Pharmaceutics | 2014 | 4 Pages |
Abstract
Macrophage induced surface degradation of poly(ethylene carbonate) (PEC) was investigated under in vitro conditions. Degradation of PEC with the MW of 41Â kDa (PEC41) was slower than that of PEC with the MW of 200Â kDa (PEC200). In terms of macrophage mediated drug release from PEC matrix, in cell-free medium, less than 1% of levofloxacin was released from both PEC samples in 10 days, while more than 60 and 20% of the drug, levofloxacin, can be detected in medium with macrophages from PEC200 and PEC41 films, respectively. This work indicated that on-demand drug delivery induced by macrophages can be achieved with PEC polymer.
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Pharmaceutical Science
Authors
Dafeng Chu, Moritz Beck-Broichsitter, Catherine Curdy, Bernd Riebesehl, Thomas Kissel,