Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5820005 | International Journal of Pharmaceutics | 2013 | 11 Pages |
Abstract
A cyclo-olefin copolymer was subjected to an e-beam ionizing treatment. Two doses were studied: one corresponding to the recommended dose for the sterilization of pharmaceutical packaging (25Â kGy), and a greater one to enhance the modifications caused by the treatment (150Â kGy). The surface modifications were studied by X-ray photoelectron spectroscopy (XPS), contact angle measurements and atomic force microscopy (AFM). The roughness and the wettability of the surface were enhanced by the treatment. The consequences of the surface modifications on the drug interaction with the polymer were studied.
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Authors
Hala Barakat, Johanna Saunier, Caroline Aymes Chodur, Pascal Aubert, Jackie Vigneron, Arnaud Etcheberry, Najet Yagoubi,