Relationship between surface properties determined by inverse gas chromatography and ibuprofen release from hybrid materials based on fumed silica

The ability of organic-inorganic hybrid materials to act as drug release-modifying agents was examined. In this study, ibuprofen, a non-steroidal anti-inflammatory drug was used as a model active pharmaceutical ingredient. The physicochemical properties of individual components of the hybrids, as well as these for two- and three-component systems were examined by inverse gas chromatography. The dispersive component of the free surface energy (γSD), KA and KD parameters describing acidity and basicity of hybrid materials, respectively, as well as Flory-Huggins parameters were determined. χ12∞ and χ′23 parameters characterize the interactions between the hybrids and a test solute, or interactions between the drug and inorganic-organic materials, respectively. Additionally, Brunauer-Emmett-Teller (BET) method was used to characterize adsorption activity of the studied materials. The prepared hybrid materials were also characterized by Fourier transform infra-red (FTIR) spectroscopy. The release profiles of ibuprofen for the created hybrid materials were determined. Relationship between the physicochemical activity of hybrid materials and ibuprofen release was presented and discussed.

Graphical abstractDownload high-res image (138KB)Download full-size image