Thermo-sensitive gels containing lorazepam microspheres for intranasal brain targeting

Scanning electron microscopy analysis of chitosan microspheres and the percentage of cumulative in vitro lorazepam release from control sample 1 (C1), control sample 2 (C2), and from test sample (S). The chitosan microspheres embedded in the hydrogel show a retarding effect on the release of lorazepam, compared with the chitosan microspheres alone. The in vitro release rate of lorazepam from microspheres suspended in thermo-sensitive gels was assessed for 24 h and was found to be prolonged.