Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5820285 | International Journal of Pharmaceutics | 2013 | 11 Pages |
Abstract
Photodynamic therapy has a great potential in the treatment of cervical cancer. The aim of this study was to develop bioadhesive pellets containing hexylaminolevulinate (HAL), a precursor of the photoactive substance PpIX, with a fast release for vaginal drug delivery. Pellets were produced by extrusion/spheronization, and Carbopol® 934 was used to obtain bioadhesive properties. A 22-factorial design with center point investigating the HAL content (1 and 10%, w/w) and Carbopol® 934 content (1 and 8%, w/w) was set up. The most suitable formulations were mechanically stable and showed bioadhesive properties toward vaginal tissue. The drug load was released within 20 min in phosphate buffer pH 4 and 6.8 in the in vitro dissolution test. The stability of HAL in the pellet formulations varied, but the most stable formulation showed 96-97% HAL remaining in the formulation after 6-7 weeks of storage at accelerated temperature conditions (40 °C). The investigated formulations seem promising for vaginal delivery of HAL.
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Authors
Marianne Hiorth, Linda Liereng, Reidun Reinertsen, Ingunn Tho,