Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5820286 | International Journal of Pharmaceutics | 2013 | 7 Pages |
Abstract
This work is focused on the fabrication of a new drug delivery system based on polyanionic matrix (e.g. sodium alginate), polycationic matrix (e.g. chitosan) and silica network. The FT-IR, SEM, DTA-TG, eukaryotic cell cycle and viability, and in vitro assay of the influence of the biocomposite on the efficacy of antibiotic drugs were investigated. The obtained results demonstrated the biocompatibility and the ability of the fabricated biocomposite to maintain or improve the efficacy of the following antibiotics: piperacillin-tazobactam, cefepime, piperacillin, imipenem, gentamicin, ceftazidime against Pseudomonas aeruginosa ATCC 27853 and cefazolin, cefaclor, cefuroxime, ceftriaxone, cefoxitin, trimethoprim/sulfamethoxazole against Escherichia coli ATCC 25922 reference strains.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Paul CÇtÇlin Balaure, Ecaterina Andronescu, Alexandru Mihai Grumezescu, Anton Ficai, Keng-Shiang Huang, Chih-Hui Yang, Carmen Mariana Chifiriuc, Yung-Sheng Lin,