| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5820416 | International Journal of Pharmaceutics | 2012 | 6 Pages |
Abstract
A unique long term stable carrier system for poorly soluble drugs was obtained by simply autoclaving nanostructured lipid carriers (NLC). NLC composed of Precirol ATO, oleic acid, glycerol 85%, Eumulgin SML 20 and water as well as NLC loaded with the poorly soluble drug Itraconazole formed a special organized matrix containing lamellar bilayers similar to biological membranes after the sterilization process. The tendency to expel the poorly soluble drug from the matrix was thereby avoided.
Graphical abstractDownload high-res image (149KB)Download full-size image
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Jana Pardeike, Sabrina Weber, Nadejda Matsko, Andreas Zimmer,