Article ID Journal Published Year Pages File Type
5820807 International Journal of Pharmaceutics 2012 11 Pages PDF
Abstract
(A) Hyperglycaemia (glucose) disrupts blood-brain barrier (BBB) integrity leading to leakage of molecules (fluorescein) from blood into brain parenchyma. (B) Dendrimers (PAMAM) scavenge glucose excess and restore BBB integrity.
Keywords
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmaceutical Science
Preview
Poly(amido)amine dendrimers generation 4.0 (PAMAM G4) reduce blood hyperglycaemia and restore impaired blood-brain barrier permeability in streptozotocin diabetes in rats
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