Spray freeze drying with polyvinylpyrrolidone and sodium caprate for improved dissolution and oral bioavailability of oleanolic acid, a BCS Class IV compound

Plasma concentration-time curves of amorphous oleanolic acid formulations processed by spray-freeze-drying of polyvinylpyrrolidone (25%, w/w) and sodium caprate (50%, w/w) with oleanolic acid (25%, w/w; Formula F), or with sodium oleanolate (25%, w/w; Formula G): and of commercial oleanolic acid tablets as reference.