Nitrones reverse hyperglycemia-induced endothelial dysfunction in bovine aortic endothelial cells

Article ID	Journal	Published Year	Pages	File Type
5823201	Biochemical Pharmacology	2016	38 Pages	PDF

Keywords

BH4 NEAA BAEC CAT MGD T1DM NADPH T2DM tetrahydrobiopterin GPX nuclear factor erythroid 2 2-NBDG JC-1 BCA DTNB PKC N-methyl-d-glucamine AGEs DAPI eNOS CMD DTPA NF-κB 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-d-glucose PBS glutathione reductase (EC 1.6.4.2)glutathione peroxidase (EC 1.11.1.9)catalase (EC 1.11.1.6)DMEM Superoxide dismutase (EC 1.15.1.1)Jnk PBN CAI NaOH SIN-1 NRF-2 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 3-morpholinosydnonimine 4′,6-diamidino-2-phenylindole c-Jun N-terminal kinase MAPK MTT NOx ONOO−ROS EDTA Endothelial dysfunction non-essential amino acids ethylenediaminetetra acetic acid Alpha lipoic acid bicinchoninic acid cardiovascular disease cardiometabolic disease EPR Electron paramagnetic resonance standard error mean dihydroethidium Type I diabetes mellitus Type II diabetes mellitus CVD SOD Sodium hydroxide, Caustic Soda Bovine aortic endothelial cells Plasma membrane nuclear factor kappa beta Advanced glycation end products Phosphate-buffered saline Dulbecco’s modified eagle’s medium SEM Nitric oxide nicotinamide adenine dinucleotide phosphate Hyperglycemia DHE Peroxynitrite High pressure liquid chromatography HPLC high glucose low glucose Reactive species Reactive oxygen species calcium ionophore

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Nitrones reverse hyperglycemia-induced endothelial dysfunction in bovine aortic endothelial cells

Authors

Colwyn A. Headley, David DiSilvestro, Kelsey E. Bryant, Craig Hemann, Chun-An Chen, Amlan Das, Ouliana Ziouzenkova, Grégory Durand, Frederick A. Villamena,