Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

Article ID	Journal	Published Year	Pages	File Type
5823419	Biochemical Pharmacology	2014	12 Pages	PDF

Keywords

NF-κB MKP-1 VPA p38MAPK MREs AREs TLR MAPKK Cyclooxygenase-2 (COX-2)HDAC LPS Jnk COX-2 MAPKKK c/ebpβ c-Jun N-terminal kinase Valproic acid (VPA)Toll-like receptor CNS Blood–brain barrier BBB brain microvascular endothelial cells central nervous system Cyclooxygenase-2 AU-rich elements nuclear factor kappa B lipopolysaccharide Histone acetyltransferase histone deacetylase Valproic acid Mitogen-activated protein kinase phosphatase-1 p38 mitogen-activated protein kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase kinase HAT

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Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

Authors

Yu-Fan Chuang, Hung-Yu Yang, Tsui-Ling Ko, Ya-Fen Hsu, Joen-Rong Sheu, George Ou, Ming-Jen Hsu,