Biosynthesis of N,N-dimethyltryptamine (DMT) in a melanoma cell line and its metabolization by peroxidases

Article ID	Journal	Published Year	Pages	File Type
5823422	Biochemical Pharmacology	2014	9 Pages	PDF

Abstract

Kynurenine-like compounds and halucinogenic molecules as products of a new characterized route of DMT metabolization involving intracellular peroxidises.

Keywords

TDO HRP IAA MAO-A DMT IDO Trp phorbol 12-myristate 13-acetate AMK FBS AFMK DMEM PBS DMK DPI MPO DMSO LC–MS/MS PMA m/z N,N-dimethyltryptamine O2−ROS Hydrogen peroxide superoxide anion 3-Indoleacetic acid indoleamine 2,3-dioxygenase tryptamine Tryptophan Tryptophan 2,3-dioxygenase TRY KYN Melanoma diphenyliodonium Dimethyl sulfoxide SOD fetal bovine serum Superoxide dismutase liquid chromatography–mass spectrometry Phosphate-buffered saline monoamine oxidase A myeloperoxidase Myeloperoxidase (MPO)Mass-to-charge ratio H2O2 Horseradish peroxidase Horseradish peroxidase (HRP)kynurenine Reactive oxygen species

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Biosynthesis of N,N-dimethyltryptamine (DMT) in a melanoma cell line and its metabolization by peroxidases

Authors

Melissa M. Gomes, Janine B. Coimbra, Renan O. Clara, Felipe A. Dörr, Ana Carolina R. Moreno, Jair R. Chagas, Sérgio Tufik, Ernani Jr, Luiz H. Catalani, Ana Campa,