Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

Article ID	Journal	Published Year	Pages	File Type
5823478	Biochemical Pharmacology	2014	38 Pages	PDF

Keywords

AMPK 3-MA DSBs ATGs γ-H2AX DAPI SA-β-gal SASP mTOR DDR GFP-LC3 TSC2 CPT CCK-8 Human colorectal cancer cells CHK2 PBS FITC 4′,6′-diamidino-2-phenylindole AMP-activated protein kinase ataxia telangiectasia mutated Small interfering RNA siRNA senescence-associated β-galactosidase Autophagy Tem Apoptosis ATM Colorectal cancer cell counting kit-8 double-strand breaks Low-dose chemotherapy Senescence-associated secretory phenotype Phosphate-buffered saline Transmission electron microscope mammalian target of rapamycin phosphorylated histone H2AX DNA damage response Propidium iodide Senescence tuberous sclerosis complex 2 autophagy-related genes camptothecin CRC Chloroquine

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Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

Authors

Jian-wei Zhang, Shan-shan Zhang, Jian-rui Song, Kai Sun, Chen Zong, Qiu-dong Zhao, Wen-ting Liu, Rong Li, Meng-chao Wu, Li-xin Wei,