| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5823494 | Biochemical Pharmacology | 2013 | 12 Pages |
Abstract
Using a yeast-based approach to screen a library of xanthones selected by docking, the pyranoxanthone was identified as p53-MDM2 inhibitor, which activated p53 and downstream signaling in human tumor cells.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Mariana Leão, Clara Pereira, Alessandra Bisio, Yari Ciribilli, Ana M. Paiva, Neuza Machado, Andreia Palmeira, Miguel X. Fernandes, EmÃlia Sousa, Madalena Pinto, Alberto Inga, LucÃlia Saraiva,