Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Article ID	Journal	Published Year	Pages	File Type
5823809	Biochemical Pharmacology	2012	13 Pages	PDF

Keywords

DTT POR HLM HRN RLM dithiothreitol Antitumour agents Metabolism Rat liver microsomes Human Liver Microsomes wild type Hypoxia

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Authors

Anita WiÅniewska, Magdalena Niemira, Karolina JagieÅÅo, Agnieszka PotÄga, MaÅgorzata Åwist, Colin Henderson, Anna Skwarska, Ewa Augustin, Jerzy Konopa, Zofia Mazerska,