Eicosapentaenoic acid improves hepatic steatosis independent of PPARÎ± activation through inhibition of SREBP-1 maturation in mice

Article ID	Journal	Published Year	Pages	File Type
5824080	Biochemical Pharmacology	2010	12 Pages	PDF

Keywords

GPAT ALT COA MTP NEFA LXR L-FABP acyl-CoA oxidase LACS ACC FATP MCAD Nuclear factor-E2-related factor 2 PGC MDA NAFLD CPT-I HTGL EPA FAS Nrf2 GPX mRNA 4-hydroxynonenal 4-HNE GAPDH AOX messenger RNA AST Aspartate aminotransferase Alanine aminotransferase apo apolipoprotein nonalcoholic steatohepatitis acetyl-CoA carboxylase Eicosapentaenoic acid Fatty acid fatty acid synthase Non-esterified fatty acid fatty acid translocase Nonalcoholic fatty liver disease Insig Medium-chain acyl-CoA dehydrogenase Fenofibrate Hepatic triglyceride lipase malondialdehyde Nash microsomal triglyceride transfer protein Fatty acid transport protein Liver fatty acid-binding protein Fat liver X receptor coenzyme A glutathione peroxidase glyceraldehyde-3-phosphate dehydrogenase glycerol-3-phosphate acyltransferase

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Eicosapentaenoic acid improves hepatic steatosis independent of PPARÎ± activation through inhibition of SREBP-1 maturation in mice

Authors

Naoki Tanaka, Xiuguo Zhang, Eiko Sugiyama, Hiroyuki Kono, Akira Horiuchi, Takero Nakajima, Hiroki Kanbe, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama,