| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5824183 | Biochemical Pharmacology | 2011 | 11 Pages |
Abstract
This study confirms that DMXAA activates both p38 and ERK1/2 MAPKs through unknown mechanisms. By using selective inhibitors of MAPKs, BIRB796 and FR180204, we confirmed that both p38 and ERK1/2 MAPK play a significant role in regulation of TNF-α and IL-6 protein production induced by DMXAA at the post-transcriptional level.
Keywords
MCP-15,6-dimethylxanthenone-4-acetic acidDMXAAMK-2RIP2IP-10nucleotide oligomerization domainNF-κBERKGAPDHNODLPSJnkIL-6c-Jun N-terminal kinaseIFNARMAPKinterferonIFNinterleukin 6ELISAEnzyme-linked immunosorbent assaynuclear factor kappa-light-chain-enhancer of activated B cellslipopolysaccharideRANTESNitric oxideAREpolymerase chain reactionPCRMonocyte chemotactic protein-1mitogen-activated protein kinaseextracellular signal-regulated kinaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Jing Sun, Liang-Chuan S. Wang, Zvi G. Fridlender, Veena Kapoor, Guanjun Cheng, Lai-Ming Ching, Steven M. Albelda,