| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5824207 | Biochemical Pharmacology | 2011 | 19 Pages |
Abstract
Research has developed a standardized, unifying mechanism of asthma and identified key targets for therapeutic intervention. Unfortunately, for 39 compounds and biologics targeted at 23 different sites in this immune cascade, so far the clinical results have uniformly failed to match expectations.
Keywords
PEFRAPCACQCTLA-4AP-1TLRSCIDICSTNFTregGM-CSFVCAM-1VLA-4NKTCytotoxic T lymphocyte-associated antigen 4TSLPICOSAQLQCysLTT helper 2 cellsNF-IL-6IgETCrmRNAICAM-1Cysteinyl leukotrienesTGFβPD-1mAbLPSAHRFEV1Very late antigen 4STATMonoclonal antibodyantigen-presenting cellEosinophils IgE, immunoglobulin EinterferonIFNinterleukinBALFFlapTransforming growth factor βToll-like receptorpeak expiratory flow ratemessenger ribonucleic acidRegulatory T cellnatural killer T cellDendritic cellT helper cellCytokinesgranulocyte-macrophage colony-stimulating factortumor necrosis factorLarThymic stromal lymphopoietinLeukotrienelipopolysaccharideBronchoalveolar lavage fluidforced expiratory volume in 1 secondmajor histocompatibility complexMHCAnimal modelsProgrammed death 1Intercellular adhesion molecule 1SCID, Severe combined immunodeficiencyEarly airway responseairway hyper-responsivenessLate asthmatic responseAsthma Control Questionnaireasthma quality-of-life questionnaire5-Lipoxygenase activating proteinactivator protein 1vascular cell adhesion protein 1prostaglandinChemokinesInducible costimulatorInhaled corticosteroidEART cell receptor
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Authors
Kevin Mullane,