Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5824315 | Biochemical Pharmacology | 2007 | 10 Pages |
Abstract
The results highlight the relevance of CTR1 for cisplatin sensitivity as there is a clear relationship between lower CTR1 expression, intracellular concentration, DNA platination and cytotoxicity of cisplatin in both resistant cell lines. Our data provide the basis for a quantitative understanding of alterations in uptake and efflux processes leading to cisplatin resistance and might hence facilitate the development of ex vivo assays that can predict cisplatin sensitivity in tumor specimens of patients.
Keywords
ribosomal protein L13HPRT1b2mATP7BATP7APBSDEPChCtr1GSHHuman copper transporter 1HUPOTFRglucuronidase beta3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideMTTβ-actinphospholipase A2AccumulationBeta-2-microglobulinUptakeTransportdiethyl pyrocarbonatecisplatinActbPhosphate buffered salineEffluxResistanceGlutathione
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Authors
Jochen Zisowsky, Susanne Koegel, Stefan Leyers, Krishna Devarakonda, Matthias U. Kassack, Maja Osmak, Ulrich Jaehde,