Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5824362 | Biochemical Pharmacology | 2008 | 6 Pages |
Abstract
Our results show that HI 6 increased the rate of decarbamylation for both physostigmine- and pyridostigmine-inhibited enzyme in both systems, the observed effect by HI 6 increasing with higher doses. Obidoxime had a slightly accelerating effect on the pyridostigmine-inhibited enzyme. MMB-4 applied to pyridostigmine-inhibited AChE in the static system only showed no difference to the experiments made in absence of oxime. No oxime showed a tendency to retard the rate of decarbamylation.
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Authors
Saskia Eckert, Peter Eyer, Marco Melzer, H. Thiermann, Franz Worek,