| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5830889 | Fitoterapia | 2014 | 7 Pages |
Abstract
Six new polycyclic polyprenylated acylphloroglucinols, attenuatumiones A-F (1-6), together with twelve known analogs (7-18) were isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic methods, and the absolute configuration of C-13 in attenuatumione C (3) was deduced via the circular dichroism datum of the in situ formed [Rh2(OCOCF3)4] complexes. All isolates were evaluated for the cytotoxic activities on three human cancer cell lines. Compound 3 showed moderate cytotoxic activities with IC50 values of 10.12 and 10.56 μM against SMMC7721 and U2OS, respectively.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Zhong-bo Zhou, Yang-mei Zhang, Ke Pan, Jian-guang Luo, Ling-yi Kong,