| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5831362 | Fitoterapia | 2013 | 5 Pages |
Abstract
Bioassay-guided phytochemical investigation on Piper longum resulted in the isolation of two new compounds. By analyses of the MS, IR, UV, 1D and 2D NMR data, the two new compounds were identified as 3β, 4α-dihydroxy-1-(3-phenylpropanoyl)-piperidine-2-one (1) and (2E, 4E, 14Z)-6-hydroxyl-N-isobutyleicosa-2,4,14-trienamide (2). In vitro anti-HBV bioassay demonstrated compound 1 possessed remarkable activity suppressing the secretion of HBeAg in Hep G2.2.15 cell line, with an IC50 value of 0.21 mM and SI value of 16.4.
Graphical abstractDownload high-res image (128KB)Download full-size image
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Zhi-Yong Jiang, Wen-Feng Liu, Chao-Guan Huang, Xiang-Zhong Huang,