| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5831500 | Fitoterapia | 2012 | 4 Pages |
Abstract
A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The key steps involve one-pot hydrazination and subsequent Bamford-Stevens reaction. The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be used for the scale-up preparation of cyclopamine.
Graphical abstractA convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The mild reaction conditions, high overall yield as well as an easy purification process give benefit for the scale-up preparation of cyclopamine.Download high-res image (107KB)Download full-size image
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Authors
Shu-Yan Zheng, Hong-Sheng Tan, Jian-Sheng Tao, Zheng-Wu Shen,