Article ID Journal Published Year Pages File Type
5831524 Fitoterapia 2012 8 Pages PDF
Abstract
The figure shows the conversion between lactone and carboxylate forms under different pH. An intact lactone ring is the critical structural feature in terms of pharmacological action. The lactone form possesses 10 times the antitumor activity of the carboxylate.67
Keywords
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
Preview
Pharmacokinetics, tissue distribution, and the lactone/carboxylate equilibrium of hydroxycamptothecin delivered via aerosol in mice
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