| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5831618 | Fitoterapia | 2012 | 5 Pages |
Abstract
Five alkaloids (1-5) were isolated from Abuta grandifolia. Compounds 3 and 4 were new bisbenzylisoquinoline alkaloids: (S-S)-O4â³-methyl,Nb-nor-O6â²-demethyl-(+)-curine and (S-S)-O4â³-methyl,O6â²-12 demethyl-(+)-curine. Alkaloids 1-5 showed acetyl- and butyrylcholinesterase inhibitory activities.82
Keywords
DTNBBChEbutyrylcholinesteraseNOEAcOHCH2Cl2TLCBW284C51CCDESInuclear magnetic resonance5,5′-dithiobis (2-nitrobenzoic acid)Iso-OMPABisbenzylisoquinoline alkaloidBisbenzylisoquinoline alkaloidsAChAChEAcetylthiocholine iodidenuclear overhauser effectAcetylcholineAcetylcholinesteraseAcetic acidMenispermaceaeAlzheimer's diseaseNMRDichloromethanecircular dichroismAChE inhibitorthin layer chromatographyCHECholinesteraseelectrospray ionization
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Maria Francesca Cometa, Stefano Fortuna, Giovanna Palazzino, Maria Teresa Volpe, Elsa Rengifo Salgado, Marcello Nicoletti, Lamberto Tomassini,