Identification of NF-ÎºB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico

Article ID	Journal	Published Year	Pages	File Type
5834474	Journal of Ethnopharmacology	2016	27 Pages	PDF

Keywords

TCM Dulbecco's modified Eagle’s medium ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry Ginsenoside Rg1 (PubChem CID: 441923)Shenfu Injection Ginsenoside Rb1 (PubChem CID: 9898279)NF- κB SFI CHD IKK HEK293 IκB NEO BMC ESI HTS NF-κB LPS DMEM DEX FBS MTT UPLC/Q-TOF-MS interleukin coronary artery disease coronary heart disease ELISA Enzyme-linked immunosorbent assay tumor necrosis factor-alpha Dexamethasone fetal bovine serum Anti-inflammation traditional Chinese medicine CAD high throughput screening Network pharmacology TNF-α nuclear factor kappa B lactate dehydrogenase LDH lipopolysaccharide inhibitor of nuclear factor kappa-B kinase inhibitor of NF-κB human embryonic kidney 293 electrospray ionization

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Identification of NF-ÎºB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico

Authors

Pan Li, Bin Lv, Xiaoqing Jiang, Ting Wang, Xianghui Ma, Nianwei Chang, Xiaoying Wang, Xiumei Gao,